Fig. 1 · Structure

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Indirubin-5-sulfonate

CDK inhibitor

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively.

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Biological Activity

Target & Activity

Target Activity Value
Cdk1/cyclin B IC50 55 nM
cdk2/cyclin A IC50 35 nM
CDK2/cyclinE IC50 150 nM
Cdk4/cyclin D1 IC50 300 nM
CDK5/p35 IC50 65 nM
GSK-3β  

6 targets · Scroll to view more

Cellular Effect

Cell Line Activity Value Description Reference
Oocyte IC50 0.055 μM Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis [PMID: 34161865]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 244021-67-8
Applications CDK inhibitor
Formula C16H10N2O5S
Molecular Weight 342.33
SMILES
O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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