INDY is a potent Dyrk1A and Dyrk1B inhibitor, acting as an ATP-competitive antagonist with IC50 values of 0.24 μM and 0.23 μM, respectively. By binding to the ATP pocket of these kinases, INDY exhibits a Ki of 0.18 μM for Dyrk1A. This compound significantly diminishes the self-renewal capacity of both normal and tumorigenic cells, making it a valuable tool for research in glioblastoma and neural progenitor cell studies.
INDY is a potent Dyrk1A and Dyrk1B inhibitor, acting as an ATP-competitive antagonist with IC50 values of 0.24 μM and 0.23 μM, respectively. By binding to the ATP pocket of these kinases, INDY exhibits a Ki of 0.18 μM for Dyrk1A. This compound significantly diminishes the self-renewal capacity of both normal and tumorigenic cells, making it a valuable tool for research in glioblastoma and neural progenitor cell studies.
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