Fig. 1 · Structure
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INI-43
Kpnβ1 Inhibitor
INI-43 is a selective inhibitor of Kpnβ1, which plays a crucial role in the nuclear localization of Kpnβ1 and its cargo proteins, including NFAT, NFκB, AP-1, and NFY. This compound has demonstrated significant anti-proliferative effects on cancer cells, promoting G2-M cell cycle arrest and inducing the intrinsic apoptosis pathway. INI-43 serves as a valuable tool for investigating the molecular mechanisms of cancer progression and exploring potential therapeutic strategies targeting Kpnβ1.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 881046-01-1 |
| Applications | Kpnβ1 Inhibitor |
| Formula | C22H23N7 |
| Molecular Weight | 385.46 |
| SMILES | NC1=C(C2=NC3=CC=CC=C3N=C2N1CCCN(C)C)C4=NC5=CC=CC=C5N4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.