Fig. 1 · Structure
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Inosine-5'-diphosphate disodium
NM23-H2 Decoy Substrate
Inosine-5'-diphosphate disodium functions as a decoy substrate for NM23-H2, demonstrating high binding affinity to the GDP-binding pocket of the enzyme (KD: 5.0 μM). This compound effectively abrogates c-MYC transcription, induces apoptosis, and causes G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions while preserving NM23-H2-mediated kinase activity. In addition to its role in cancer research, particularly in Burkitt's lymphoma, it exhibits antihypoxic, antihyperthermic, and antiarrhythmic properties, providing protective effects against γ-irradiation in animal models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 54735-61-4 |
| Applications | NM23-H2 Decoy Substrate |
| Formula | C10H14N4O11P2 |
| Molecular Weight | 428.19 |
| Synonyms | IDP disodium; Inosine-5'-diphosphoric acid disodium |
| SMILES | O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.