Fig. 1 · Structure
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Inosine-5'-diphosphate
NM23-H2 Decoy Substrate
Inosine-5'-diphosphate (IDP) serves as a decoy substrate for NM23-H2, exhibiting high affinity for the GDP-binding pocket (KD: 5.0 μM). This compound effectively inhibits c-MYC transcription and induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions, while preserving NM23-H2’s kinase activity. Additionally, IDP possesses antihypoxic, antihyperthermic, and antiarrhythmic properties, providing protective effects against γ-irradiation. It is applicable in research concerning Burkitt's lymphoma and cardiovascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 86-04-4 |
| Applications | NM23-H2 Decoy Substrate |
| Formula | C10H14N4O11P2 |
| Molecular Weight | 428.19 |
| Synonyms | IDP; Inosine-5'-diphosphoric acid |
| SMILES | O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.