IOX 2

Catalog No.: A11924
HIF-PHD inhibitor
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
Grouped product items
Product Name Price Stock Qty
IOX 2 10mg
Special Price $68.00 Regular Price $85.00
In stock
IOX 2 25mg
Special Price $144.00 Regular Price $180.00
In stock
IOX 2 50mg
Special Price $256.00 Regular Price $320.00
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Biological Activity
Discription IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
Targets
Target Value
Product Information
Catalog Num A11924
Formula C19H16N2O5
Molecular Weight 352.3
CAS Number 931398-72-0
SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
Synonyms IOX-2, IOX2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 7 mg/mL (19.86 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.38 mL 141.92 mL 283.85 mL
0.5 mM 5.68 mL 28.38 mL 56.77 mL
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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