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2OG oxygenases Inhibitor

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Catalog No. A14277

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
IOX1 10mg A14277-10
IOX1 25mg A14277-25
IOX1 50mg A14277-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.


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Chemical Information

Catalog Num A14277
Actions Inhibitor
M. Wt 189.17
Formula C10H7NO3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 5852-78-8
Synonyms IOX 1, Iox-1

Biological Activity

IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
Target Value
KDM3AIC50: 0.1μM
KDM4CIC50: 0.6μM
KDM6BIC50: 1.6μM
KDM2AIC50: 1.8μM
KDM4EIC50: 2.3μM
KDM5CIC50: 19μM
PHD2IC50: 33μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 52.86 mL 264.31 mL 528.63mL
0.5 mM 10.57 mL 52.86 mL 105.73 mL
1 mM 5.29 mL 26.43 mL 52.86 mL
5 mM 1.06 mL 5.29 mL 10.57 mL

*The above data is based on the productmolecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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