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IP6C

Thoeris System Inhibitor

IP6C is a specific inhibitor targeting the type II Thoeris immune system, effectively competing with histidine binding in the catalytic pocket of ThsB. By inhibiting His-ADPR alarm signal production, IP6C facilitates phage replication by relieving bacterial stasis. Notably, IP6C resensitizes drug-resistant bacteria, such as Pseudomonas aeruginosa, to phage lysis without affecting non-targeted bacteria or exhibiting toxicity to mammalian cell lines. This compound significantly enhances the survival rate of infected mice, making it a valuable tool for investigating bacterial phage defense mechanisms and studying Pseudomonas aeruginosa infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	103313-38-8
Applications	Thoeris System Inhibitor
Formula	C₈H₇N₃O
Molecular Weight	161.16
SMILES	NC(C1=CN2C=CN=C2C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.