Fig. 1 · Structure
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Ipatasertib-NH2 dihydrochloride
Ligand For Target Protein
Ipatasertib-NH2 dihydrochloride serves as a ligand for the target protein AKT, functioning within the PROTAC (INY-03-041) platform. This compound includes Ipatasertib-NH2 linked through a ten-carbon linker to a CRBN ligand, Lenalidomide, facilitating interactions with the E3 ubiquitin ligase. It is a valuable tool for investigating the degradation of AKT and exploring therapeutic avenues in cancer and other diseases characterized by dysregulated AKT signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1001264-73-8 |
| Applications | Ligand For Target Protein |
| Formula | C21H28Cl3N5O2 |
| Molecular Weight | 488.84 |
| Synonyms | GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride |
| SMILES | C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.