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Biological Activity
IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5±1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
| In vitro | DMSO | 83 mg/mL (182.21 mM) | |
| Water | Insoluble | ||
| Ethanol | 11 mg/mL (24.15 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.95 mL | 109.77 mL | 219.53 mL |
| 0.5 mM | 4.39 mL | 21.95 mL | 43.91 mL |
| 1 mM | 2.2 mL | 10.98 mL | 21.95 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
*The above data is based on the productmolecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16800 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1425043-73-7 |
| Formula | C25H25N7O2 |
| M. Wt | 455.51 |
| Purity | >98% |
| Synonyms | IPI3063, IPI 3063 |
| SMILES | O=C1N(C)C=C(C2=CC=CC(C=C([[email protected]@H](NC3=C(C#N)C(N)=NC=N3)C)N4C(C)C)=C2C4=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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