Fig. 1 · Structure
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Ipivivint
CLK Inhibitor
Ipivivint is a potent orally active inhibitor of CDC-like kinases (CLKs), demonstrating an EC50 of 1 nM for CLK2 and 7 nM for CLK3 in human studies. Additionally, it effectively inhibits the Wnt signaling pathway with an EC50 of 13 nM and tyrosine phosphorylation-regulated kinase 1A (TPRK1A) at an EC50 of 5 nM. This compound is valuable for research applications focused on CLKs and related signaling pathways, contributing to the understanding of various biological processes and potential therapeutic targets.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1481617-15-5 |
| Applications | CLK Inhibitor |
| Formula | C26H21FN8 |
| Molecular Weight | 464.50 |
| SMILES | CN(C)CC1=CC(C2=CN=C(NN=C3C(N4)=NC5=C4C(C6=CC(F)=CC=C6)=CN=C5)C3=C2)=CN=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.