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Ipomoeassin F

ER Protein-Translocation Inhibitor

Ipomoeassin F is a potent and selective inhibitor of endoplasmic reticulum (ER) protein translocation, acting by targeting the pore-forming subunit Sec61α of the Sec61 complex at the ER membrane. This compound effectively inhibits the ER membrane translocation of SARS-CoV-2 proteins, making it a valuable tool in virology research. Additionally, Ipomoeassin F obstructs the translocation of secretory proteins and type I transmembrane proteins while leaving type III transmembrane proteins unaffected, allowing for nuanced studies of protein transport mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	915392-44-8
Applications	ER Protein-Translocation Inhibitor
Formula	C₄₄H₆₂O₁₅
Molecular Weight	830.95
Synonyms	Ipom-F
SMILES	O=C(/C=C/C1=CC=CC=C1)O[C@H]([C@](COC(CCC(CCCCCC2)=O)=O)([H])O[C@](O[C@@]([C@@H](O)[C@H]3OC(C)=O)([H])[C@](O[C@@H]3C)([H])O[C@H]2CCCCC)([H])[C@@H]4O)[C@@H]4OC(/C(C)=C/C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.