Fig. 1 · Structure
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Irdabisant hydrochloride
H3 Receptor Agonist
Irdabisant hydrochloride is a selective inverse agonist of the histamine H3 receptor (H3R), demonstrating high affinity with Ki values of 7.2 nM for rat H3R and 2.0 nM for human H3R. This compound exhibits cognition-enhancing and wake-promoting properties, as evidenced in the rat social recognition model. Due to its ability to penetrate the blood-brain barrier and its relatively low inhibitory activity on hERG current, Irdabisant hydrochloride is suitable for research applications focused on schizophrenia and cognitive impairment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1005398-61-7 |
| Applications | H3 Receptor Agonist |
| Formula | C18H24ClN3O2 |
| Molecular Weight | 349.86 |
| Synonyms | CEP-26401 hydrochloride |
| SMILES | C[C@H](CCC1)N1CCCOC2=CC=C(C(C=C3)=NNC3=O)C=C2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.