Fig. 1 · Structure
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IRF1-IN-1
IRF1 Inhibitor
IRF1-IN-1 is a selective inhibitor of Interferon Regulatory Factor 1 (IRF1) that effectively decreases IRF1 recruitment to the CASP1 promoter. This compound inhibits key elements of the cell death signaling pathway, including the cleavage of Caspase 1, Gasdermin D (GSDMD), and poly(ADP-ribose) polymerase 1 (PARP1), thereby modulating inflammatory responses. Additionally, IRF1-IN-1 demonstrates a protective effect against ionizing radiation-induced inflammatory skin injury, making it a valuable tool in studies of inflammation and cell death mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 701225-07-2 |
| Applications | IRF1 Inhibitor |
| Formula | C22H24N4O4S |
| Molecular Weight | 440.52 |
| SMILES | O=C1C2=C(N=CN1CCC(NC3=CC=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.