Fig. 1 · Structure
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IRF1-IN-2
IRF1 Inhibitor
IRF1-IN-2 is a potent inhibitor of interferon regulatory factor 1 (IRF1), targeting its recruitment to the promoter region of CASP1. This compound effectively disrupts the cell death signaling pathway by inhibiting the cleavage of key proteins, including Caspase 1, GSDMD, IL-1, and PARP1, while upregulating GPX4 and downregulating FACL4. IRF1-IN-2 demonstrates protective effects against inflammatory skin injuries induced by ionizing radiation, making it a valuable tool in research focused on apoptosis and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 708245-32-3 |
| Applications | IRF1 Inhibitor |
| Formula | C18H20N2O4S |
| Molecular Weight | 360.43 |
| SMILES | O=C(NC1=CC=C(S(=O)(N2CCCC2)=O)C=C1)C3=CC=CC=C3OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.