Fig. 1 · Structure
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Isamoltan hydrochloride
5-HT1B Antagonist
Isamoltan hydrochloride is a selective antagonist of the 5-HT1B receptor, exhibiting an IC50 value of 39 nM for the inhibition of [125I]ICYP binding to 5-HT1B recognition sites in rat brain membranes. Additionally, it acts as a β-adrenoceptor ligand with an IC50 of 8.4 nM. This compound demonstrates anxiolytic activity and is valuable in research exploring anxiety-related disorders and serotonergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 99740-06-4 |
| Applications | 5-HT1B Antagonist |
| Formula | C16H23ClN2O2 |
| Molecular Weight | 310.82 |
| Synonyms | (±)-Isamoltane hydrochloride |
| SMILES | OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.