Fig. 1 · Structure
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ISM012-042
PHD Inhibitor
ISM012-042 is a potent PHD1 and PHD2 inhibitor with IC50 values of 1.9 nM and 2.5 nM, respectively. It exhibits protective effects on Caco-2 cells against DSS-induced barrier disruption and demonstrates anti-inflammatory properties in lipopolysaccharide (LPS)-stimulated mouse bone marrow-derived dendritic cells (BMDC), where it reduces the expression of IL-12p35 and TNF in a dose-dependent manner. This compound is effective in restoring intestinal barrier function and alleviating intestinal inflammation in various experimental models of colitis, making it a valuable tool for research in intestinal mucosal repair and immune disease studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2924181-80-4 |
| Applications | PHD Inhibitor |
| Formula | C25H27N7O4 |
| Molecular Weight | 489.53 |
| SMILES | CC(C)(OC(N1CCN(C2=CC=C3C(C=NC(C(NCC4=CN=C(C#N)C=C4)=O)=C3O)=N2)CC1)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.