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iso-ADP ribose

Ligand

Iso-ADP ribose (isoADPr) functions as a ligand for the modification of proteins and nucleic acids. It consists of two consecutive ADP-ribosyl units within the poly(ADP-ribose) (PAR) chain, serving as a critical signaling molecule. Iso-ADP ribose activates the RING finger protein 146 (RNF146) by binding to the basic Lys61 residue within its RING domain, facilitating various biological processes. This compound is essential for studies related to protein regulation and post-translational modifications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	15720-01-1
Applications	Ligand
Formula	C₁₅H₂₃N₅O₁₄P₂
Molecular Weight	559.32
SMILES	NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.