Isosorbide dinitrate

Catalog No.: A17565

Nitric oxide donor

Isosorbide dinitrate

Isosorbide dinitrate Chemical Structure

CAS NO. 87-33-2

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

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500 mg
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Biological Activity

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
In vitro DMSO 46 mg/mL (194.8 mM)
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 42.35 mL 211.75 mL 423.5 mL
0.5 mM 8.47 mL 42.35 mL 84.7 mL
1 mM 4.23 mL 21.17 mL 42.35 mL
5 mM 0.85 mL 4.23 mL 8.47 mL

*The above data is based on the productmolecular weight 236.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17565
CAS No. 87-33-2
Formula C6H8N2O8
M. Wt 236.13
Purity >98%
Synonyms Isosorbide dinitrate; Disorlon; NSC 80038; NSC-80038; NSC80038; SST-101; Dilatrate SR; Korodil;
SMILES O=[N+]([O-])O[[email protected]]1[[email protected]@H](OC[[email protected]]2O[N+]([O-])=O)[[email protected]@H]2OC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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