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Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.35 mL | 211.75 mL | 423.5 mL |
| 0.5 mM | 8.47 mL | 42.35 mL | 84.7 mL |
| 1 mM | 4.23 mL | 21.17 mL | 42.35 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.47 mL |
*The above data is based on the productmolecular weight 236.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17565 |
|---|---|
| M. Wt | 236.13 |
| Formula | C6H8N2O8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 87-33-2 |
| Synonyms | Isosorbide dinitrate; Disorlon; NSC 80038; NSC-80038; NSC80038; SST-101; Dilatrate SR; Korodil; |
| SMILES | O=[N+]([O-])O[[email protected]]1[[email protected]@H](OC[[email protected]]2O[N+]([O-])=O)[[email protected]@H]2OC1 |
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