Fig. 1 · Structure
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Isotanshinone IIA
Phosphatase
Isotanshinone IIA is an abietane-type diterpene that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) with an IC50 of 11.4 μM. This compound demonstrates significant potential in regulating insulin signaling and has implications for research in metabolic disorders and diabetes. Its ability to modulate phosphatase activity makes it a valuable tool for investigating signal transduction pathways in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 20958-15-0 |
| Applications | Phosphatase |
| Formula | C19H18O3 |
| Molecular Weight | 294.34 |
| SMILES | O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1C(C)=CO4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.