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ISR activator 2

ISR Activator

ISR Activator 2 is a selective activator of the integrated stress response (ISR), primarily targeting the cytosolic pattern recognition receptor RIG-I. By binding to RIG-I, it notably activates the heme-regulated inhibitor (HRI) ISR kinase without invoking an interferon response. This compound is especially relevant for research into pancreatic cancer, offering insights into the mechanisms of stress response and potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	332874-88-1
Applications	ISR Activator
Formula	C₂₃H₂₁N₃O₃S₂
Molecular Weight	451.56
SMILES	CC1=CC(C)=NC(SCC(NC2=C(C(OCC)=O)C(C3=CC=CC=C3)=CS2)=O)=C1C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.