Fig. 1 · Structure
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Itacnosertib hydrochloride
ACVR1 inhibitor
Itacnosertib hydrochloride is a potent inhibitor of ACVR1 (ALK2), with an IC50 of 8 nM, as well as FLT3 and JAK2, exhibiting IC50 values of 6 nM and 8540 nM respectively. This compound demonstrates significant anti-leukemic activity, making it valuable for research in hematological malignancies. It is suitable for studies focused on delineating the role of ACVR1 in cancer biology and evaluating therapeutic strategies targeting this pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2409543-84-4 |
| Applications | ACVR1 inhibitor |
| Formula | C26H29ClN8O |
| Molecular Weight | 505.01 |
| Synonyms | TP-0184 hydrochloride |
| SMILES | CN1CCN(C2=CC=C(NC3=NC=CC(NC4=CC=CN=C4C5=NC=CC=C5)=N3)C=C2OC)CC1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.