Fig. 1 · Structure
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ITK antagonist
ITK Antagonist
ITK antagonist is a selective inhibitor of Interleukin-2 inducible T-cell kinase (ITK) with an IC50 value of 1 nM and 20 nM in various assays. This compound is orally active and has shown the ability to inhibit insulin receptor kinase (IRK) with an IC50 of 160 nM. It is valuable for research applications focused on T-cell signaling pathways and the modulation of immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1149753-56-9 |
| Applications | ITK Antagonist |
| Formula | C26H34N6O2S |
| Molecular Weight | 494.65 |
| SMILES | CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.