Fig. 1 · Structure
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ITK inhibitor 5
ITK Inhibitor
ITK inhibitor 5 is a selective inhibitor targeting the interleukin-2-inducible T-cell kinase (ITK) with an IC50 of 5.6 nM. Demonstrating low activity against Bruton's tyrosine kinase (BTK) with an IC50 of 25 nM, this compound is useful in studying T-cell signaling pathways and immune responses. It serves as an effective tool in research aimed at understanding the role of ITK in various hematological disorders and inflammatory diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2404603-41-2 |
| Applications | ITK Inhibitor |
| Formula | C21H18F2N4O2 |
| Molecular Weight | 396.39 |
| SMILES | C=CC(NCCOC1=C2C=C(NC2=CC=C1)C3=NNC4=C3C=CC(C(F)F)=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.