Fig. 1 · Structure
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ITK inhibitor 6
ITK Inhibitor
ITK inhibitor 6 is a highly selective inhibitor of ITK with an IC50 of 4 nM. This compound also demonstrates weaker activity against BTK, JAK3, EGFR, and LCK, with IC50 values of 133 nM, 320 nM, 2360 nM, and 155 nM, respectively. ITK inhibitor 6 effectively inhibits the phosphorylation of PLCγ1 and ERK1/2 pathways and exhibits significant antiproliferative activity. It is a valuable tool for research applications focused on lymphocyte signaling and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2404604-06-2 |
| Applications | ITK Inhibitor |
| Formula | C28H24F2N4O2 |
| Molecular Weight | 486.51 |
| SMILES | C=CC(NCCOC1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C4=NNC5=C4C=CC(C(F)F)=C5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.