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ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.92 mL | 134.61 mL | 269.22 mL |
| 0.5 mM | 5.38 mL | 26.92 mL | 53.84 mL |
| 1 mM | 2.69 mL | 13.46 mL | 26.92 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
*The above data is based on the productmolecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A20934 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 347323-96-0 |
| Formula | C22H17N3OS |
| M. Wt | 371.45 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | ITX 3, ITX-3 |
| SMILES | O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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