Fig. 1 · Structure
Documents & Downloads
IWP-12
Acyltransferase Inhibitor
IWP-12 is a potent inhibitor of the acyltransferase porcupine (PORCN), significantly impacting cell-autonomous Wnt signaling pathways. With an IC50 value of 15 nM, IWP-12 effectively disrupts the Wnt signaling cascade, making it a valuable tool for studying the role of Wnt in various biological processes and diseases. This compound is particularly useful in cancer research and developmental biology applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 688353-45-9 |
| Applications | Acyltransferase Inhibitor |
| Formula | C18H18N4O2S3 |
| Molecular Weight | 418.56 |
| SMILES | O=C1C2=C(N=C(N1C)SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)CC(C)S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.