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IWP-2

Name: IWP-2
Brand: Adooq Bioscience
SKU: A12707
Availability: InStock

Cat. No. A12707 CAS 686770-61-6

Wnt inhibitor

IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.

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Biological Activity

Target & Activity

Target	Activity	Value
Wnt (Cell-free assay)		27 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
CAPAN-1	EC50	2.05 μM	Antiproliferative activity against human Capan1 cells after 48 hrs by MTT assay	[PMID: 29630366]
HEK293	EC50	2.76 μM	Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay	[PMID: 29630366]
HT-29	EC50	4.67 μM	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 29630366]
MIA PaCa-2	EC50	1.9 μM	Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay	[PMID: 29630366]
PANC-1	EC50	2.33 μM	Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay	[PMID: 29630366]
SW-620	EC50	1.9 μM	Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay	[PMID: 29630366]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	686770-61-6
Applications	Wnt inhibitor
Formula	C₂₂H₁₈N₄O₂S₃
Molecular Weight	466.6
Synonyms	IWP 2,IWP2
SMILES	CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	Insoluble
Water	Insoluble
Ethanol	DMF: 24mg/mL (51.44 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.