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Publications citing Adooq Products
Chemical Information
| Catalog Num | A12707 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 466.6 |
| Formula | C22H18N4O2S3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 686770-61-6 |
| Synonyms | IWP 2,IWP2 |
| SMILES code | CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4 |
| Chemical Name | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
Description |
IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 29 mg/mL (62.15 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.43 mL | 107.16 mL | 214.32mL |
| 0.5 mM | 4.29 mL | 21.43 mL | 42.86 mL |
| 1 mM | 2.14 mL | 10.72 mL | 21.43 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
*The above data is based on the productmolecular weight 466.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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Special Price Starting at:
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IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylatin ...
Special Price Starting at: $98.00
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