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Izicopan

C5a Receptor Antagonist

Izicopan (INF056) is a potent antagonist of the complement factor C5a receptor, effectively disrupting C5a-mediated signaling pathways. It demonstrates significant inhibition of C5a-induced calcium mobilization, with an IC50 in the range of 10-100 nM. This compound is valuable for research into inflammatory responses and immune modulation, making it a crucial tool for studies focused on autoimmune diseases and related therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2489430-53-5
Applications	C5a Receptor Antagonist
Formula	C₃₃H₃₁F₈N₃O₂
Molecular Weight	653.61
Synonyms	INF056
SMILES	O=C(C1=C(C=CC=C1F)F)N2[C@@H](C3=CC=C(C=C3)NC4CCCC4)[C@H](C[C@H](C2)C(F)(F)F)C(NC5=CC(C(F)(F)F)=C(C=C5)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.