Fig. 1 · Structure
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Izuforant
H4R Antagonist
Izuforant is a potent histamine H4 receptor (H4R) antagonist, exhibiting an IC50 of 36 nM against human H4R. This compound also demonstrates a binding affinity for the human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. Izuforant is characterized by its significant anti-pruritic and anti-inflammatory properties, making it a valuable tool for research into allergic responses and inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1429374-83-3 |
| Applications | H4R Antagonist |
| Formula | C12H12BrN7 |
| Molecular Weight | 334.17 |
| Synonyms | JW1601 |
| SMILES | CNC1CN(C2=NC3=NC=C(Br)C=C3N4C2=NN=C4)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.