Fig. 1 · Structure
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(±)-J-113397 (racemic)
ORL1 Receptor Antagonist
(±)-J-113397 is a selective non-peptidyl antagonist of the ORL1 receptor, exhibiting a Ki value of 1.8 nM for cloned human ORL1. It effectively inhibits nociceptin/orphanin FQ-stimulated GTPγS binding in CHO cells expressing ORL1, with an IC50 of 5.3 nM. This compound is valuable for investigating the physiological roles and functions of the nociceptin/orphanin FQ system in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 217461-40-0 |
| Applications | ORL1 Receptor Antagonist |
| Formula | C24H37N3O2 |
| Molecular Weight | 399.57 |
| SMILES | O=C1N([C@](CCN2CC3CCCCCCC3)([H])[C@H](C2)CO)C4=CC=CC=C4N1CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.