(±)-J-113397 is a selective non-peptidyl antagonist of the ORL1 receptor, exhibiting a Ki value of 1.8 nM for cloned human ORL1. It effectively inhibits nociceptin/orphanin FQ-stimulated GTPγS binding in CHO cells expressing ORL1, with an IC50 of 5.3 nM. This compound is valuable for investigating the physiological roles and functions of the nociceptin/orphanin FQ system in various biological contexts.
(±)-J-113397 is a selective non-peptidyl antagonist of the ORL1 receptor, exhibiting a Ki value of 1.8 nM for cloned human ORL1. It effectively inhibits nociceptin/orphanin FQ-stimulated GTPγS binding in CHO cells expressing ORL1, with an IC50 of 5.3 nM. This compound is valuable for investigating the physiological roles and functions of the nociceptin/orphanin FQ system in various biological contexts.
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