J5 peptide

Name: J5 peptide
Brand: Adooq Bioscience
SKU: A90830
Rating: 5 (288 reviews)

Catalog No.: A90830

MBP Inhibitor

J5 peptide is a competitive inhibitor of myelin basic protein (MBP) that prevents the binding of MBP85-99 to HLA-DR2. This peptide has demonstrated efficacy in alleviating PLP139-151/MBP85-99-induced experimental autoimmune encephalomyelitis (EAE) in murine models. J5 peptide is relevant for research on inflammatory and immune diseases, particularly in studies targeting autoimmune mechanisms.

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Biological Activity

Description	J5 peptide is a competitive inhibitor of myelin basic protein (MBP) that prevents the binding of MBP85-99 to HLA-DR2. This peptide has demonstrated efficacy in alleviating PLP139-151/MBP85-99-induced experimental autoimmune encephalomyelitis (EAE) in murine models. J5 peptide is relevant for research on inflammatory and immune diseases, particularly in studies targeting autoimmune mechanisms.

Product Information

Catalog Num	A90830
Formula	C70H114N18O21
Molecular Weight	1543.76
CAS Number	444305-16-2
Sequence	Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala
Sequence shortening	EKPKVEAYKAAAAPA
SMILES	C([C@@H](NC([C@H](CCC(O)=O)N)=O)CCCCN)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(O)=O)C)=O)CCC3)C)=O)C)=O)C)=O)C)=O)CCCCN)=O)=O)C)=O)CCC(O)=O)=O)[C@@H](C)C)=O)CCCCN)=O)CCC1
Synonyms	Myelin basic protein (85-99) antagonist

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