Fig. 1 · Structure
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Jagged-1 (188-204)
Notch Agonist
Jagged-1 (188-204) is a Notch agonist derived from the Jagged-1 protein, known for its role in activating the Notch signaling pathway. This peptide fragment exhibits significant biological activity by enhancing the maturation of monocyte-derived human dendritic cells. It is particularly relevant for research in multiple myeloma, where Jagged-1 is highly expressed in both cultured and primary tumor cells, making it a valuable tool for studies focused on immune response and cancer immunotherapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 219127-21-6 |
| Applications | Notch Agonist |
| Formula | C93H127N25O26S3 |
| Molecular Weight | 2107.40 |
| SMILES | O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.