JAK1-IN-4

Catalog No.: A18821
JAK1 inhibitor
JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).
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Product Name Price Stock Qty
JAK1-IN-4 1mg
Special Price $256.00 Regular Price $320.00
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JAK1-IN-4 5mg
Special Price $768.00 Regular Price $960.00
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JAK1-IN-4 10mg
Special Price $1,280.00 Regular Price $1,600.00
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Biological Activity
Discription JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).
Targets
Target Value
Product Information
Catalog Num A18821
Formula C26H32FN9O2
Molecular Weight 521.59
CAS Number 2091134-35-7
SMILES O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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