JAK1-IN-4

Catalog No.: A18821

JAK1 inhibitor

JAK1-IN-4

JAK1-IN-4 Chemical Structure

CAS NO. 2091134-35-7

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.86 mL 191.72 mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.59 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

*The above data is based on the productmolecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18821
Actions Inhibitor
CAS No. 2091134-35-7
Formula C26H32FN9O2
M. Wt 521.59
Solubility DMSO
Purity >98%
SMILES O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[[email protected]](N5CCN([[email protected]@H](C5)C)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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