Fig. 1 · Structure
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JAK2-IN-11
Stable Isotope
JAK2-IN-11 is a potent inhibitor of the JAK2 kinase, exhibiting an IC50 value of less than 10 nM against both the wild-type and V617F mutant forms of the JH2 domain. This compound demonstrates significant antitumor activity, making it a valuable tool for research focused on cancer therapeutics and the role of JAK2 in cellular signaling pathways. Its application extends to studies investigating the molecular mechanisms underlying JAK2-mediated malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3057053-17-2 |
| Applications | Stable Isotope |
| Formula | C31H28D3F3N8O4 |
| Molecular Weight | 639.64 |
| SMILES | O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=NC5=C(C=CC=C5C(F)(F)F)C(C(N6CCC(CC6)C#N)=O)=C4)=NC=C3N1C([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.