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JE-133

Neuroprotectant

JE-133 is an optically active isochromane-2H-chromene conjugate that acts as a neuroprotectant by targeting the PI3K/Akt and MAPK signaling pathways. This compound exhibits significant antioxidant and anti-inflammatory properties, effectively inhibiting neuronal oxidative damage. Additionally, JE-133 modulates neuroinflammation induced by lipopolysaccharide (LPS) through the regulation of the JAK/STAT and Nrf2 signaling pathways, making it a valuable tool for research into neuroprotective mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2579171-69-8
Applications	Neuroprotectant
Formula	C₂₃H₂₄O₇
Molecular Weight	412.43
SMILES	CCOC([C@@H]1C([C@H]2C3=CC(O)=C(O)C=C3C[C@H](O2)C)=CC4=CC(OC)=CC=C4O1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.