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JF-NP-26

mGlu5R Negative Allosteric Modulator

JF-NP-26 is a photocaged derivative of raseglurant that acts as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R). When activated by light pulses at 405 nm, JF-NP-26 demonstrates light-dependent analgesic effects in models of inflammatory and neuropathic pain in vivo. This unique capability provides valuable insights into the modulation of mGlu5 receptors and their role in pain pathways, facilitating research in neuropharmacology and pain management.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2341841-03-8
Applications	mGlu5R Negative Allosteric Modulator
Formula	C₃₀H₂₈FN₃O₄
Molecular Weight	513.56
SMILES	O=C(OCC(C1=CC=C(N(CC)CC)C=C1O2)=CC2=O)NC3=C(C)C=C(C)N=C3C#CC4=CC=CC(F)=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.