JF-NP-26 is a photocaged derivative of raseglurant that acts as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R). When activated by light pulses at 405 nm, JF-NP-26 demonstrates light-dependent analgesic effects in models of inflammatory and neuropathic pain in vivo. This unique capability provides valuable insights into the modulation of mGlu5 receptors and their role in pain pathways, facilitating research in neuropharmacology and pain management.
JF-NP-26 is a photocaged derivative of raseglurant that acts as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R). When activated by light pulses at 405 nm, JF-NP-26 demonstrates light-dependent analgesic effects in models of inflammatory and neuropathic pain in vivo. This unique capability provides valuable insights into the modulation of mGlu5 receptors and their role in pain pathways, facilitating research in neuropharmacology and pain management.
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