Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

JG-98

Catalog No.: A18734

Hsp70 inhibitor

JG-98

JG-98 Chemical Structure

CAS NO. 1456551-16-8

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

Availability: In stock

Package Price Qty
5 mg
$320.00
10 mg
$520.00
50 mg
$1,500.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Shivani Patel, .et al. Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module, iScience, 2022, Apr 22;25(5):104282 PMID: 35573186

Biological Activity

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
In vitro DMSO 7 mg/mL (13.09 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.71 mL 93.54 mL 187.08 mL
0.5 mM 3.74 mL 18.71 mL 37.42 mL
1 mM 1.87 mL 9.35 mL 18.71 mL
5 mM 0.37 mL 1.87 mL 3.74 mL

*The above data is based on the productmolecular weight 534.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18734
Actions Inhibitor
CAS No. 1456551-16-8
Formula C24H21Cl2N3OS3
M. Wt 534.54
Purity >98%
Synonyms JG98, JG 98
SMILES CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy JG-98 | JG-98 Supplier | purchase | cost | manufacturer | order | distributor | buy 1456551-16-8| 1456551-16-8 Supplier | purchase 1456551-16-8 | 1456551-16-8 cost | 1456551-16-8 manufacturer | order 1456551-16-8 | 1456551-16-8 distributor
Rewards