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- Shivani Patel, .et al. Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module, iScience, 2022, Apr 22;25(5):104282 PMID: 35573186
Biological Activity
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.
| In vitro | DMSO | 7 mg/mL (13.09 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.71 mL | 93.54 mL | 187.08 mL |
| 0.5 mM | 3.74 mL | 18.71 mL | 37.42 mL |
| 1 mM | 1.87 mL | 9.35 mL | 18.71 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
*The above data is based on the productmolecular weight 534.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18734 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1456551-16-8 |
| Formula | C24H21Cl2N3OS3 |
| M. Wt | 534.54 |
| Purity | >98% |
| Synonyms | JG98, JG 98 |
| SMILES | CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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