JH-II-127

Catalog No.: A15777

LRRK2 inhibitor

JH-II-127

JH-II-127 Chemical Structure

CAS NO. 1700693-08-8

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $120.00

Special Price $108.00

10 mg

Regular Price: $200.00

Special Price $180.00

25 mg

Regular Price: $400.00

Special Price $360.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.94 mL 239.89 mL
0.5 mM 4.8 mL 23.99 mL 47.98 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15777
Actions Inhibitor
M. Wt 416.86
Formula C19H21ClN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1700693-08-8
Synonyms N/A
SMILES CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC

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