Fig. 1 · Structure
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JH-LPH-107
LpxH Inhibitor
JH-LPH-107 is a selective inhibitor of LpxH, an enzyme crucial for lipopolysaccharide biosynthesis in gram-negative bacteria. This compound demonstrates a low incidence of spontaneous resistance, making it a valuable tool for investigating bacterial pathogenesis and antibiotic resistance mechanisms. Its high safety profile in vitro supports its potential applications in antimicrobial research and drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3053068-92-8 |
| Applications | LpxH Inhibitor |
| Formula | C25H25ClF3N5O5S2 |
| Molecular Weight | 632.07 |
| SMILES | O=C(NC1=CC=C(S(=O)(N2CCN(C3=NC(Cl)=CC(C(F)(F)F)=C3)CC2)=O)C=C1)C4=CC=CC=C4N(C)S(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.