Fig. 1 · Structure
Documents & Downloads
JH-VIII-49
PROTAC Target Protein Ligand
JH-VIII-49 is a potent and selective inhibitor of CDK8, exhibiting an IC50 value of 16 nM. Its unique steroid backbone design facilitates effective CDK8 inhibition, making it a valuable reagent for chemical research. JH-VIII-49 serves as a target protein ligand in the synthesis of PROTAC, specifically for the compound JH-XI-10-02, thereby advancing studies in targeted protein degradation and related therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2209084-73-9 |
| Applications | PROTAC Target Protein Ligand |
| Formula | C30H40N2 |
| Molecular Weight | 428.65 |
| SMILES | C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.