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Biological Activity
JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.44 mL | 137.19 mL | 274.39 mL |
| 0.5 mM | 5.49 mL | 27.44 mL | 54.88 mL |
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
*The above data is based on the productmolecular weight 364.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18774 |
|---|---|
| Actions | Stabilizer |
| CAS No. | 2234281-75-3 |
| Formula | C22H24N2O3 |
| M. Wt | 364.45 |
| Purity | >98% |
| Synonyms | JI051; JI-051; JI 051 |
| SMILES | O=C(NCCC1=CC=CC=C1OCC)/C=C/C(N2)=CC3=C2C(OC)=CC=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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