Fig. 1 · Structure
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JI130
Hes1-PHB2 Stabilizer
JI130 is a stabilizer of the Hes1-PHB2 interaction, acting to inhibit the repressive transcriptional activity of Hes1. This compound has demonstrated significant efficacy in suppressing tumor growth in murine models of pancreatic cancer, indicating its potential applications in cancer management. JI130 may serve as a valuable tool for researchers investigating the regulatory mechanisms of Hes1 in oncogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Stabilizer |
| CAS Number | 2234271-86-2 |
| Applications | Hes1-PHB2 Stabilizer |
| Formula | C23H24N2O3 |
| Molecular Weight | 376.45 |
| SMILES | O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.