JKC363

Name: JKC363
Brand: Adooq Bioscience
SKU: A23436
Rating: 5 (288 reviews)

Catalog No.: A23436

MC4 receptor antagonist

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

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JKC363 436083-30-6 <p>MC4 receptor antagonist</p>

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Grouped product items
Size	Price	Stock
1mg	$40.00	In stock
5mg	$135.00	In stock
10mg	$230.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

Product Information

Catalog Num	A23436
Formula	C69H91N19O16S2
Molecular Weight	1506.71
CAS Number	436083-30-6
Sequence	{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)
Sequence shortening	{Mpa}-EH-{D-2-Nal}-RWGCPPKD-NH2 (Disulfide bridge:Mpa1-Cys8)
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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