Fig. 1 · Structure
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JMS-17-2 hydrochloride
CX3CR1 Antagonist
JMS-17-2 hydrochloride is a potent and selective antagonist of the CX3CR1 receptor, exhibiting an IC50 of 0.32 nM. This compound has been shown to impair metastatic seeding and colonization of breast cancer cells, making it a valuable tool for cancer researchers investigating metastasis and related pathways. Its specificity for CX3CR1 allows for targeted studies in various disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2341841-07-2 |
| Applications | CX3CR1 Antagonist |
| Formula | C25H27Cl2N3O |
| Molecular Weight | 456.41 |
| SMILES | O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.