Fig. 1 · Structure
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JMV-1645
B1 Bradykinin Receptor Antagonist
JMV-1645 is a highly selective antagonist of the B1 bradykinin receptor, exhibiting a Ki value of 0.023 nM in human cloned B1 receptors. This compound is instrumental in researching various indications related to trauma and infection, facilitating the study of bradykinin-mediated pathophysiological processes. Its potency makes it a valuable tool for understanding the role of B1 receptors in inflammatory responses and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 284037-77-0 |
| Applications | B1 Bradykinin Receptor Antagonist |
| Formula | C49H69N13O12S |
| Molecular Weight | 1064.22 |
| SMILES | NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](C1Cc2ccccc2C1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(O)=O)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.