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JNJ-28312141 hydrochloride

FMS Inhibitor

JNJ-28312141 hydrochloride is a potent inhibitor of the colony-stimulating factor-1 receptor (CSF-1R or FMS) with an IC50 of 0.69 nM. This compound effectively inhibits the proliferation of various cancer cell lines, including BDBM, MV-4-11, M-o7e, and TF-1, with IC50 values of 2.6 nM, 21 nM, 41 nM, and 150 nM, respectively. Additionally, JNJ-28312141 hydrochloride demonstrates anti-inflammatory properties in mouse models of arthritis, supporting its potential use in research related to both cancer and inflammatory disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1149939-55-8
Applications	FMS Inhibitor
Formula	C₂₆H₃₃ClN₆O₂
Molecular Weight	497.03
SMILES	O=C(C1=NC(C#N)=CN1)NC2=C(C3=CCCCC3)C=C(C4CCN(C(CN(C)C)=O)CC4)C=C2.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.