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| Description | JNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. |
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| Catalog Num | A18325 |
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| Formula | C20H12F2N6 |
| Molecular Weight | 374.355 |
| CAS Number | 943540-74-7 |
| SMILES | FC(C1=CC=C2N=CC=CC2=C1)(F)C3=NN=C4C=CC(C5=CC=NC=C5)=NN43 |
| Synonyms | JNJ38877618, JNJ 38877618 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 9 mg/mL (24.04 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.71 mL | 133.56 mL | 267.13 mL |
| 0.5 mM | 5.34 mL | 26.71 mL | 53.43 mL |
| 1 mM | 2.67 mL | 13.36 mL | 26.71 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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