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JNJ-42905343

PHD1/2/3 Inhibitor

JNJ-42905343 is a selective prolyl hydroxylase (PHD1/2/3) inhibitor, demonstrating pKI values of 8.07, 7.48, and 7.27 for the respective isoforms. This compound effectively regulates hypoxia-inducible factor (HIF) signaling, making it a valuable tool for investigating functional iron deficiency (FID) and the anemia of chronic disease (ACD). Its oral bioavailability and specificity position it as a significant reagent in research focused on oxygen sensing and erythropoiesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1238689-36-5
Applications	PHD1/2/3 Inhibitor
Formula	C₂₀H₁₅FN₄O₄
Molecular Weight	394.36
SMILES	O=C(C1=CN(C(NC2=C3C=C(OC4=C(C)C=CC=C4C)C(F)=C2)=NC3=O)N=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.