Fig. 1 · Structure
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JNJ-46281222
mGlu2 PAM
JNJ-46281222 is a highly potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGlu2, exhibiting nanomolar affinity with a Kd value of 1.7 nM. This compound shows significant modulatory potency, with a pEC50 value of 7.71. It serves as a valuable tool for research applications focused on neuropharmacology, particularly in the context of disorders related to glutamatergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1254980-38-5 |
| Applications | mGlu2 PAM |
| Formula | C23H25F3N4 |
| Molecular Weight | 414.47 |
| SMILES | FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.